何创龙

发布部门:生物与医学工程学院 发布时间:2022-07-05





个人简介

何创龙,教授,博士生导师,生物制造与组织再生课题组负责人。2004年获重庆大学生物医学工程专业博士学位,并先后在同济大学和美国密歇根大学进行博士后研究。主要从事生物材料、组织工程、纳米医学等领域的研究。先后主持科技部重点研发计划、国家自然科学基金等科研项目30多项;在Advanced MaterialsAdvanced Functional MaterialsACS NanoBioactive Materials等学术期刊上发表论文220多篇;获授权国家发明专利35项;先后入选Elsevier“中国高被引学者”榜单、全球学者库“全球顶尖前10万科学家”榜单、斯坦福大学发布全球前2%顶尖科学家榜单年度科学影响力排行榜。为国际华人骨研学会终身会员。担任国际期刊Composites part B: Engineering编委和ACS Biomaterials Science & Engineering顾问编委。任中国生物材料学会骨修复材料与器械分会副主任委员、中国解剖学会血管分会副主任委员、上海市生物材料专业委员会副主任委员等职务。

近年来,本课题组特别注重科研成果的转化与应用,并与企业共同开发了丝素蛋白可吸收再生修复膜、生物活性玻璃创面敷料、3D打印骨缺损修复材料等产品。


研究方向

1. 骨、软骨、关节、血管修复材料

2. 生物打印与人体类器官

3. 创面修复材料

4. 骨和关节疾病诊疗材料与技术

5. 可穿戴智能材料与器件


荣誉及获奖情况

1. 第三届国产大频韵母亲子乱网学竞赛指导教师一等奖2019年)

2. 上海市第一届大学生生命科学竞赛特等奖(指导教师)2019年)

3. 香港桑麻基金会桑麻奖教金(2018年)

4. 第三届国产大频韵母亲子乱网学创新创业大赛指导教师一等奖(2018年)

5. 上海市科学技术奖自然科学三等奖(2015年)


主持与承担国家级科研项目:

1.国家重点研发计划2022YFC24030002022.11-2025.10,课题骨干,在研。

2.国家重点研发计划2018YFB11056002018.5-2021.4,课题主持,结题。

3.国家自然科学基金面上项目(32271412),2023.1-2026.12,主持,在研。

4.国家自然科学基金面上项目(32071350),2021.1-2024.12,主持,在研。

5. 国家自然科学基金面上项目317710482018.1-2021.12,主持,结题。

6. 国家自然科学基金面上项目315709842016.1-2019.12,主持,结题。

7. 国家自然科学基金面上项目312710282013.1-2016.12,主持,结题。


代表性学术论文:

1. Lu ZY, Du S, Li JX, Zhang M, Nie HL, Zhou XJ, Li FL, Wei XW, Wang JQ, Liu FY, He CL*, Yang G*, Gu Z*. Langmuir-Blodgett-mediated formation of antibacterial microneedles for long-term transdermal drug delivery. Advanced Materials, 2023, DOI: 10.1002/adma.202303388.

2. Guo ST, He CL*. Bioprinted scaffold remodels the neuromodulatory microenvironment for enhancing bone regeneration, Advanced Functional Materials, 2023, 2304172.

3. Zhou XJ, Qian YH, Chen L, Li T, Sun X, Ma XJ*, Wang JW*, He CL*. Flowerbed-inspired biomimetic scaffold with rapid internal tissue infiltration and vascularization capacity for bone repair. ACS Nano, 2023, 17(5): 5140-5156.

4. Shi TT, Lu HZ, Zhu JY, Zhou XJ, He CL*, Li FL*, Yang G*. Naturally derived dual dynamic crosslinked multifunctional hydrogel for diabetic wound healing. Composites Part B: Engineering, 2023, 257: 110687.

5. Sun X, Yang J, Ma J, Wang TC, Zhao X, Zhu D, Jin WJ, Zhang K, Sun XZ, Shen YL, Xie N, Yang F, Li S, Zhou XJ, He CL*, Zhang DT*, Wang JW*. Three-dimensional bioprinted BMSCs-laden highly adhesive artificial periosteum containing gelatin-dopamine and graphene oxide nanosheets promoting bone defect repair. Biofabrication, 2023, 15(2): 025010.

6. Fu LW, Feng Q, Chen YJ, Fu JZ, Zhou XJ, He CL*. Nanofibers for the immunoregulation in biomedical applications. Advanced Fiber Materials, 2022, 4:1334-1356.

7. Nie W, Dai XY, Copus JS, Kengla K, Xie RY, Seeds M, Atala A*, He CL*.  Rapid mineralization of graphene-based 3D porous scaffolds by semi-dry electrodeposition for photothermal treatment of tumor-induced bone defects. Acta Biomaterialia, 2022, 153: 573-584.

8. Li SK, Li ZH, Yang J, Ha YJ, Zhou XJ*, He CL*. Inhibition of sympathetic activation by delivering calcium channel blockers from a 3D printed scaffold to promote bone defect repair. Advanced Healthcare Materials, 2022, 11(16): 2200785.

9. Li ZH, Li SK, Yang J, Ha YJ, Zhang QQ, Zhou XJ*, He CL*. 3D bioprinted gelatin/gellan gum-based scaffold with double-crosslinking network for vascularized bone regeneration.Carbohydrate Polymers, 2022, 290: 119469.

10. Ha YJ, Ma XJ, Li SK, Li T, Li ZH, Qian YH, Shafiq M, WangJW, Zhou XJ*, He CL*. Bone microenvironment-mimetic scaffolds with hierarchical microstructure for enhanced vascularization and bone regeneration, Advanced Functional Materials, 2022, 32, 2200011.

11. Fu LW, Zhang WY, Zhou XJ, Fu JZ*, He CL*. Tumor cell membrane -camouflaged responsive nanoparticles enable MRI-guided immuno-chemodynamic therapy of orthotopic osteosarcoma. Bioactive Materials, 2022, 17: 221-233.

12. Gu JN, Zhang QQ, Geng MR, Wang WZ, Yang J, Atta ur Rehman Khan, Du HB, Sha Z, Zhou XJ*, He CL*. Construction of nanofibrous scaffolds with interconnected perfusable microchannel networks for engineering of vascularized bone tissue. Bioactive Materials, 2021, 6(10): 3254-3268.

13. Chai NW, Zhang JT, Zhang QQ, Du HB, He X, Yang J, Zhou XJ*, He JW*, He CL*. Construction of 3D printed constructs based on microfluidic microgel for bone regeneration. Composites Part B: Engineering, 2021, 223: 109100.

14. Xue S, Zhou XJ, Shan WL, Wang C, Lu HM, Xu YM, Zhong YM, Zhu LB*, He CL*, Ma JZ*. Cartilage-targeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy.Bioactive Materials, 2021, 6(8): 2372-2389.

15. Cai JY, Zhang QQ, Chen JB, Jiang J, Mo XM, He CL*, Zhao JZ*. Electrodeposition of calcium phosphate onto polyethylene terephthalate artificial ligament enhances graft-bone integration after anterior cruciate ligament reconstruction. Bioactive Materials, 2021, 6(3): 783-793.

16. He X, Liu XZ, Yang J, Du HB, Chai NW, Sha Z, Geng MR, Zhou XJ*, He CL*. Tannic acid-reinforced methacrylated chitosan/methacrylated silk fibroin hydrogels with multifunctionality for accelerating wound healing. Carbohydrate Polymers, 2020, 247: 116689.

17.Yang SG, Chen L, Zhou XJ, Sun P, Fu LW, You YL, Xu M, You ZW, Kai GY*, He CL*. Tumor-targeted biodegradable multifunctional nanoparticles for cancer theranostics.Chemical Engineering Journal, 2019, 378: 122171.

18. Liu DH, Nie W, Li DJ, Wang WZ, Zheng LX, Zhang JT, Zhang JL, Peng C, Mo XM, He CL*. 3D printed PCL/SrHA scaffold for enhanced bone regeneration. Chemical Engineering Journal, 2019, 362: 269-279.

19. Chen L, Zhang JL, Zhou XJ, Yang SG, Zhang QQ, Wang WZ, You ZW, Peng C*, He CL*. Merging metal organic framework with hollow organosilica nanoparticles as versatile nanoplatform for cancer theranostics. Acta Biomaterialia, 2019, 86: 406-415.

20. Wang WZ, Nie W, Zhou XJ, Feng W, Chen L, Zhang QQ, You ZW, Shi QS*, Peng C*, He CL*. Fabrication of heterogeneous porous bilayered nanofibrous vascular grafts by two-step phase separation technique. Acta Biomaterialia, 2018, 79: 168-181.

21. Chen L, Zhou XJ, Nie W, Feng W, Zhang QQ, Wang WZ, Zhang YZ, Chen ZG, Huang P*, He CL*. Marriage of albumin-gadolinium complexes and MoS2 nanoflakes as cancer theranostics for dual-modality magnetic resonance/photoacoustic imaging and photothermal therapy. ACS Applied Materials & Interfaces, 2017, 9 (21): 17786-17798.

22. Chen L, Feng YH, Zhou XJ, Zhang QQ, Nie W, Wang WZ, Zhang YZ, He CL*. One-pot synthesis of MoS2 nanoflakes with desirable degradability for photothermal cancer therapy. ACS Applied Materials & Interfaces, 2017, 9 (20): 17347-17358.

23. Nie W, Peng C, Zhou XJ, Chen L, Wang WZ, Zhang YZ, Ma PX*, He CL*. Three-dimensional porous scaffold by self-assembly of reduced graphene oxide and nano-hydroxyapatite composites for bone tissue engineering. Carbon, 2017, 126: 325-337.

24.Chen L, Zhou XJ, Nie W, Zhang QQ, Wang WZ, Zhang YZ, He CL*. Multifunctional redox-responsive mesoporous silica nanoparticles for efficient targeting drug delivery and magnetic resonance imaging. ACS Applied Materials & Interfaces, 2016, 8 (49): 33829-33841.

25. Qiu KX, Chen B, Nie W, Zhou XJ, Feng W, Wang WZ, Chen L, Mo XM, Wei YZ, He CL*. Electrophoretic deposition of dexamethasone-loaded mesoporous silica nanoparticles onto poly(L-lactic acid)/poly(ε–caprolactone) composite scaffold for bone tissue engineering. ACS Applied Materials & Interfaces, 2016, 8 (6): 4137-4148.

26. Zhou XJ, Feng W, Qiu KX, Chen L, Wang WZ, Nie W, Mo XM, He CL*. BMP-2 derived peptide and dexamethasone incorporated mesoporous silica nanoparticles for enhanced osteogenic differentiation of bone mesenchymal stem cells. ACS Applied Materials & Interfaces, 2015, 7 (29): 15777-15789.

27. Feng W, Zhou XJ, Nie W, Chen L, Qiu KX, Zhang YZ, He CL*. Au/ polypyrrole@Fe3O4 nanocomposites for MR/CT dual-modal imaging guided- photothermal therapy: an in vitro study. ACS Applied Materials & Interfaces, 2015, 7(7): 4354-4367.

28. Feng W, Nie W, He CL*, Zhou XJ, Chen L, Qiu KX, Wang WZ, Yin ZQ. Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers. ACS Applied Materials & Interfaces, 2014, 6 (11): 8447-8460.

29. He CL, Jin XB, Ma PX. Calcium phosphate deposition rate, structure and osteoconductivity on electrospun poly(l-lactic acid) matrix using electrodeposition or simulated body fluid incubation. Acta Biomaterialia, 2014, 10(1): 419-427.

30. He CL, Xiao GY, Jin XB, Sun CH, Ma PX. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography. Advanced Functional Materials, 2010, 20(20): 3568-3576.


主讲课程

高级组织工程学(博士生)

组织工程(硕士生)

生物材料学(本科生)


联系方式

邮箱:hcl@dhu.edu.cn;办公室电话:021-67792666;科研主页:https://orcid.org/0000-0001-8330-8542